Conference Program

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Friday, October 24, 2008


9:00 - 18:00 PM     Registration (Lobby, Friendship Palace)

Saturday, October 25, 2008


8:00 - 8:15 AM      Opening Ceremony (Ballroom, Friendship Palace)


                                  Chairs: Shuiping Jiang (UK), George F Gao (China)



8:15 - 9:15AM       Keynote Lecture (Ballroom, Friendship Palace)


                                  Chair: Ethan Shevach, National Institutes of Health, USA


                                  Shimon Sakaguchi, Kyoto University, Japan

                                  Regulatory T cells for immune tolerance and homeostasis



9:15 - 9:30 AM      Coffee Break



9:30 - 12:35 AM    Plenary Session 1: Development and Molecular Control of Regulatory T Cells (Ballroom, Friendship Palace)


                                  Chairs: Alexander Rudensky (USA), Yong-Jun Liu (USA)


9:30 - 9:55 AM        Alexander Rudensky, University of Washington, USA

                                  Determinants of regulatory T cell development and function


9:55 - 10:20 AM       Ludger Klein, University of Munich, Germany

                                   Intrathymic development of natural regulatory T cells


10:20 - 10:45 AM     Yong-Jun Liu, Anderson Cancer Center, USA

                                   Two functional subsets of Foxp3+ regulatory T cells in human thymus and periphery 


10:45 - 11:10 AM     Thomas Malek, University of Miami, USA

                                   IL-2 receptor signaling in T regulatory cell development, homeostasis, and function


11:10 - 11:35 AM     Xuetao Cao, Second Military Medical University, China

                                   Induction of regulatory T cells by regulatory antigen-presenting cells


11:35 - 11:50 AM     Short Talk: Yun-Cai Liu, La Jolla Institute for Allergy and Immunology, USA

                                   The E3 ubiquitin ligase Itch regulates Foxp3 expression and airway inflammation


11:50 –12:05 PM      Short Talk: Mike Farrar, University of Minnesota, USA

                                   Linked T cell receptor and cytokine signaling govern the development of regulatory T cell repertoire


12:05 – 12:20 PM     Short Talk: Jean Pieters, University of Basel, Switzerland

                                   Regulation of T cell subsets by coronin 1 mediated intracellular signaling.


12:20 – 12:35 PM     Short Talk: Li Wu, The Walter and Eliza Hall Institute of Medical Research, Australia

                                   The migratory CD8loSirpa+ dendritic cell subset in the thymus is specialized in T-regulatory cell induction



12:35 - 14:40 PM     Buffet Lunch (Juheyuan Restaurant, Friendship Palace), Poster Setup and Poster Viewing (Poster Room, Friendship Palace)



13:10 - 14:20 PM     Lunch Oral Session I (Ballroom, Friendship Palace)


                                     Chairs: Kingston Mills (Ireland), Xiaoming Gao (China)


13:10 – 13:20 PM       Biao Zheng, Baylor College of Medicine, USA

                                     Germinal center helper T-cells are dual functional regulatory cells with suppressive activity to conventional CD4+ T-cells


13:20 – 13:30 PM       Wenwei Tu, University of Hong Kong, China

                                     Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naïve precursors by CD40-activated B cells (0046)


13:30 – 13:40 PM       Bin Wang, China Agricultural University, China

                                     Suppression of antigen specific allergic and autoimmune responses by in vivo induction of regulatory DC that converts naïve T cells to adaptive Tr cells


13:40 – 13:50 PM       Hong Zhang, Northwestern University, USA

                                     Induced PLP peptide-specific regulatory T cells appear to suppress experimental autoimmune encephalomyelitis in an antigen-specific manner.


13:50 – 14:00 PM       Frank J. Ward, University of Aberdeen, UK

                                    Stimulation of CD4+ regulatory T cells to secrete the effector T cell inhibitor, soluble CTLA-4


14:00 - 14:10 PM       Jude E. Uzonna, University of Manitoba, Canada

                                   The phosphoinsotide 3 kinase (PI3K) controls susceptibility to Leishmania major by regulating expansion and effector function of regulatory T cells


14:10 - 14:20 PM       Amy Putnam, University of California at San Francisco, USA

                                    Moving Tregs to the clinic: expansion and characterization of human regulatory T cells



14:40 - 16:25 PM     Plenary Session 2: Induction of Regulatory T Cells (Ballroom, Friendship Palace)


                                    Chairs: Harald von Boehmer (USA), Jingwu Zang (China)


14:40 - 15:05 PM        Harald von Boehmer, Harvard University, USA

                                     Prospective Treg induction by a single epitope achieves multi-epitope transplantation tolerance


15:05 - 15:30 PM        Jingwu Zang, GlaxoSmithKline R&D China, China

                                     Impaired function of regulatory T cells and role of T cell vaccination in rheumatoid arthritis


15:30 – 15:45 PM       Short Talk: Stefan Beissert, University of Muenster, Germany

                                     UV-induced regulatory T cells: phenotype and function


15:45 – 16:00 PM       Short Talk: Xin Xiao Zheng, University of Pittsburgh, USA

                                    A new pathway of differentiating double-negative regulatory T cells: novel cell-based therapeutic approach.



16:00 - 16:15 PM    Coffee Break



16:15 - 18:05PM     Plenary Session 3: Dynamics and Stability of Regulatory T Cells in Regulation (Ballroom, Friendship Palace)


                                    Chairs: Xuetao Cao (China), Jeffrey Bluestone (USA)


16:15 -16:40 PM        Jeffrey Bluestone, University of California at San Francisco, USA

                                    Stability of Tregs critical in control of autoimmunity


16:40 - 17:05PM       Ciriaco Piccirillo, McGill University, Canada

                                    Functional dynamics of CD4+Foxp3+ regulatory T cells in organ-specific autoimmunity: In vivo veritas


17:05 - 17:20 PM       Short Talk: Alf Hamann, Charite Berlin, Germany

                                    Epigenetic regulation of Foxp3 and Treg stability


17:20 - 17:35 PM       Short Talk: Xian C Li, Harvard University, USA

                                    OX40 reprograms Foxp3+ Tregs to Foxp3+ inflammatory cells that mediate transplant rejection and autoimmunity 


17:35 - 17:50PM        Short Talk: Xiao-Feng Qin, MD Anderson Cancer Center, USA

                                    The origin and dynamic behavior of tumor-associated Foxp3+ regulatory T cells


17:50 – 18:05 PM      Short Talk: Makoto Miyara, Kyoto University, Japan; and University of Paris 6, France

                           Functional delineation and differentiation dynamics of FoxP3-expressing subpopulations of CD4+ T cells in humans



18:40 - 22:00 PM    Welcome Reception and Buffet Diner (Ballroom and Juheyuan Restaurant, Friendship Palace)



Sunday, October 26, 2008


8:00 - 10:30 AM     Plenary Session 4: Mechanism of Suppression and Molecular Signaling of Regulatory T Cells (Ballroom, Friendship Palace)


                                   Chairs: Ethan Shevach (USA), Wanjun Chen (USA)


8:00 - 8:25 AM         Ethan Shevach, National Institutes of Health, USA

                                   Control of immune responses by natural and adaptive regulatory T cells


8:25 - 8:50 AM         Wanjun Chen, National Institutes of Health, USA

                                  TGF-b control of CD4+CD25+Foxp3+ regulatory T cells: regulating the regulator


8:50 - 9:15 AM         Megan Levings, University of British Columbia, Canada

                                   Molecular regulation of human regulatory T cells


9:15 - 9:40 AM         Yang-Xin Fu, University of Chicago, USA

                                   Treg tempers initial innate responses


9:40 - 9:55 AM         Short Talk: Bin Li, University of Pennsylvannia, USA

                                   Foxp3 biochemistry in regulatory T cells - how diverse signals regulate suppression


9:55 - 10:10 AM       Short Talk: Yisong Wan, University of North Carolina, USA

                                   A critic and specific role for Brg in regulating Treg function


10:10 – 10:25 AM     Short talk: Ye Zheng, University of Washington, USA

                                    Regulatory T cell suppressor program co-opts transcription factor IRF4 to control Th2 responses


10:25 – 10: 40 AM    Short Talk: Qizhi Tang, University of California, San Francisco, USA

                                    Regulatory T cells impede autoimmune diabetes by preventing dendritic cell maturation in inflamed islets


10: 40 – 10:55 AM     Short Talk: Kristin Tarbell, National Institutes of Health, USA

                                    The role of IL-1 inhibitors for regulatory T cell induction and function



10:55 - 11:10 AM     Coffee Break



11:10 - 13:10 AM     Plenary Session 5: Diversity of Regulatory T Cells (Ballroom, Friendship Palace)


                                     Chairs: Maria Grazia Roncarolo (Italy), Wei He (China)


11:10 -11:35 AM        Maria Grazia Roncarolo, San Raffaele Telethon Institute for Gene Therapy, Italy

                                     Biology and clinical application of natural and inducible regulatory T cells in humans


11:35 - 12:00PM         Terry Delovitch, Robarts Research Institute, Canada

                                     Extent of Treg-iNKT cell cooperation for protection from type 1 diabetes varies between treatment with Th2-biased and -unbiased glycolipid antigents


12:00 - 12:25 PM        Vipin Kumar, Torrey Pines Institute for Molecular Studies, USA

                                    CD8aa+TCRab+ regulatory/suppressor T cells  


12:25- 12:50 PM         Li Zhang, University of Toronto, Canada

                                    Double negative regulatory T cells - non-conventional regulators


12:50 - 13:10 PM       Wei He, Chinese Academy of Medical Sciences, China

                                    gd T cells in immunoregulation



13:10 - 14:45 PM    Buffet Lunch (Juheyuan Restaurant, Friendship Palace), and Poster Viewing (Rooms 1-3, Friendship Palace)



13: 40 – 14: 30 PM   Lunch Oral Session II (Ballroom, Friendship Palace)


                                      Chairs: Terry Delovitch (Canada), Baoping Wang (China)


13:40 – 13: 50 PM       Itay Shalev, University of Toronto, Canada

                                     The immunoregulatory role of FGL2 as a novel effector cytokine of Treg cells


13:50 – 14:00 PM       Qing-Sheng Mi, Henry Ford Health System, USA

                                     The miRNAs regulate iNKT cell development and maturation


14:00 – 14:10 PM       Yan Wu, Harvard Medical School, USA

                                     CD39/ENTPD1 expression by CD4+/Foxp3+ regulatory T cells inhibits NK cell-mediated antitumor activity


14:10 – 14:20 PM       Leigh Guerin, University of Adelaide, Australia

                                    The influence of interleukin 10 on regulatory T cell abundance in pregnancy


14:20 - 14:30 PM       Asha Pillai, Stanford University, USA

                                    Host natural killer T cells induce an IL-4 dependent expansion of donor CD4+CD25+Foxp3+ Tregs that protects against graft-versus-host disease



14:45 - 16:35 PM    Plenary Oral Session 1: Tregs: Basic Sciences (Ballroom, Friendship Palace)


                                    Chairs: Richard Flavell (USA), Ludger Klein (Germany)


14:45 - 14:55 PM        Georgina Kalodimos, Centenary Institute of Cancer Medicine and Cell Biology, Australia

                                    The role of T cell receptor avidity in thymic regulatory T cell development


14:55 - 15:05 PM       Bernd Arnold, German Cancer Research Center, Germany

                                    Dickkopf 3, a novel modulator of T cell responses


15:05 - 15:15 PM       Colleen Winstead, University of Minnesota, USA

                                    CD4+CD25+Foxp3+ regulatory T cells maintain peripheral tolerance in the context of T cell LIP through preservation of TCR diversity


15:15 - 15:25 PM       Zhaocai Zhou, University of Pennsylvania School of Medicine, USA

                                    Structural insights into FOXP3 homo-oligomerization


15:25 - 15:35 PM       Nina Oberle, German Cancer Research Center, Germany

                                    Suppression mechanisms in human CD4+CD25- T cells upon interaction with naturally occurring regulatory T cells


15:35 - 15:45 PM       Erika Cretney, The Walter and Eliza Hall Institute of Medical Research, Australia

                                   A crucial role for Blimp-1 in regulatory T cells


15:45 - 15:55 PM       Kajsa Wing, Kyoto University, Japan

                                    CTLA-4 expression is critical for CD4+Foxp3+ regulatory T cell function


15:55 - 16:05 PM       Zihai Li, University of Connecticut School of Medicine

                                    Heat shock protein gp96 (grp94, HSP90b1) potentiates regulatory T cell function via chaperoning Toll-like receptor 4


16:05 - 16:15 PM       Qian Chen, National Institutes of Health, USA

                                    Engagement of TLR2 promotes mouse regulatory T cell survival


16:15 - 16:25 PM       Yogesh Singh, The Royal Veterinary College, UK

                                   Antigen-specific designer regulatory T cells: an immunotherapeutic approach to ameliorate autoimmune type 1 diabetes


16:25 - 16:35 PM       Karin Loser, University of Muenster, Germany

                                   CD4+CD25+ regulatory T cells expanded in peripheral lymph nodes via RANKL-RANKL activated epidermal Langerhans cells suppress cutaneous inflammation and colitis



16:35 - 16:50 PM    Coffee Break



16:40 -18:30 PM     Plenary Short Talk Session 2: Tregs: Clinical Application (Ballroom, Friendship Palace)


                                    Chairs: Fiona Powrie (UK), Thomas Malek (USA)


16:50 - 17:00 PM       Giuseppina Pennesi, Advanced Biotechnology Center, Italy

                                    Generation of CD4+C25+ Treg mediated by mesenchymal stem cells in experimentally induced sarcomas


17:00 - 17:10 PM       Todd Brusko, University of California at San Francisco, USA

                                    Development of engineered antigen-specific human regulatory T cells by viral TCR gene transfer


17:10 - 17:20 PM       Abdelaziz Amrani, University of Sherbrooke, Canada

                                    TSLP induces Treg differentiation and protection from autoimmune diabetes in NOD mice.


17:20 - 17:30 PM       Ana Claudia Zenclussen, Otto-von-Guericke University, Germany

                                    Regulatory T cells: Key players in maternal tolerance towards the fetus


17:30 - 17:40 PM       Laurence Weiss, Université Paris Descartes, France

                                    Regulatory T cells in chronically HIV-infected patients interrupting an effective antiretroviral therapy


17:40 - 17:50 PM       Raewyn Broady, University of British Columbia, Canada

                                    Development of a modified skin explant assay to study interactions between T regulatory and Th17 cells in human skin.


17:50 - 18:00 PM       Xunrong Luo, Northwestern University, USA

                                    ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via expansion of CD4+CD25+Foxp3+ Treg cells


18:00 - 18:10 PM       Luis Graca, University of Lisbon, Portugal

                                    Induction of antigen-specific tolerance to aeroallergens: regulation without regulatory T cells.


18:10 - 18:20 PM       David Game, Imperial College London, UK

                                   Tregs in human transplantation: FoxP3 is not enough


18:20 - 18:30 PM      Yang Dai, Torrey Pines Institute for Molecular Studies, USA

                                   Clonal choice mediated by processing of flanking residues of a dominant GAD65 determinant is involved in T cell regulation in type 1 diabetes



18:45 - 19:30 PM    Special Session: Journal Editorial Policies and Process (Ballroom, Friendship Palace)


                                    Chairs: Shuiping Jiang (UK), Xuetao Cao (China)


                                    Dr John Foley, Associate Editor of Science (Science Signaling)

                                    Dr Clare Thomas, Senior Editor of Nature Medicine

                                    Dr Christine Borowski, Senior Editor of Nature Immunology

                                    Dr Lucy Bird, Acting Chief Editor of Nature Review Immunology



Monday, October 27, 2008


8:00 - 10:25 AM     Plenary Session 6: Tregs, Teff, and Autoimmune Disease (Ballroom, Friendship Palace)


                                   Chairs: C Garrison Fathman (USA), David Hafler (USA)


8:00 - 8:25 AM         C Garrison Fathman, Stanford University, USA

                                   Treg and CD4+ Teff interactions result in anergy in the regulated cells


8:25 - 8:50 AM         David Hafler, Harvard University, USA

                                   The Balance of Human CD4+CD25high Regulatory T cells and Th17 Effector Cells


8:50 - 9:15 AM         Richard Flavell, Yale University, USA

                                  Tregs and Th17 cell dynamics


9:15 - 9:40 AM         Stephen Miller, Northwestern University, USA

                                  A role for Tregs in controlling susceptibility/resistance and tolerance in immune-mediated demyelinating diseases


9:40 - 9:55 AM         Short Talk: Eva Huter, National Institutes of Health, USA

                                  Antigen-specific TGF-beta-induced Treg suppress Th17-mediated autoimmune disease


9:55 – 10:10 AM       Short Talk: Jean M Fletcher, Trinity College Dublin, Ireland

                                    CD39+ FoxP3+ Treg cells suppress pathogenic Th17 cells



10:10 - 10:25 AM   Coffee Break



10:25 - 12:30 AM   Plenary Session 7: Regulatory T Cells in Infection and Cancer (Ballroom, Friendship Palace)


                                   Chairs: Weiping Zou (USA), Tyler J Curiel (USA)


10:25 - 10:50 AM      Kingston  H. G. Mills, Trinity College, Ireland

                                   Manupulating Treg cell induction by modulating dendritic cell activation in the development of therapies for cancer and autoimmunity


10:50 - 11:15 AM     Weiping Zou, University of Michigan, USA

                                   Regulatory T cell compartmentalization and trafficking


11:15 - 11:40 PM      Tyler J Curiel, University of Texas Health Sciences Center, USA

                                   Managing regulatory T cells as a novel  cancer treatment strategy


11:40 - 11:55 PM      Short Talk: Fu-Sheng Wang, Beijing Insitute of Infectious Diseases, China

                                   Increased regulatory T cells impair CD8+ T-cell function and correlate with poor survival of patients with HBV-associated hepatocellular carcinoma


11:55 - 12:10 PM      Short Talk, Lishan Su, Institute of Biophysics, CAS, China

                                   Distinctive roles of FoxP3+ Treg cells during acute & chronic HIV-1 infection & immuno-pathogenesis


12:10 - 12:25 PM       Short Talk: Philipp Beckhove, German Cancer Research Center, Germany

                                    Identification of a highly individual and polyvalent repertoire of tumour antigen specific regulatory T cells in colorectal cancer patients



12:25 - 14:15 PM     Buffet Lunch (Juheyuan Restaurant, Friendship Palace), and Poster Viewing (Rooms 1-3, Friendship Palace)



13:00 – 14:00 PM    Lunch Oral Session III (Ballroom, Friendship Palace)


                                     Chairs: Hans-Dieter Volk (Germany), Bing-Yi Shi (China)


13:00 – 13:10 PM       Yanmei Han, Second Military Medical University, China

                                     CD69+CD4+CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-β1


13:10 –13:20 PM        Yu-Fang Cui, Institute of Radiation Medicine, China

                                     Regulatoy T cell is associated with pathogenesis of mouse colitis and therapeutic effect of CLYSTER No.1 on colitis


13:20 – 13:30 PM       Chung-Hao Chao, Chang Gung University, Taiwan, China

                                     The role of TNFRII-expressed regulatory T cells in patients with decompensated liver cirrhosis


13:30 – 13:40 PM       Yun Ma, King’s College London, UK

                                     Predominance of intrahepatic Th1 effectors and impairment of CD4+CD25+ T-regs may contribute to the perpetuation of liver damage in autoimmune hepatitis


13:40 – 13:50 PM       Hongjun Wang, Harvard Medical School, USA

                                     Bilirubin and carbon monoxide induce tolerance towards islet allograft by modulating T regulatory T cells


13:50 – 14:00 PM       Huifang Chen, Université de Montréal, Canada

                                    Adoptive transfer of CD4+CD25+ regulatory cells combined with low-dose sirolimus preserves suppressive function of regulatory T cells and delayed acute rejection of renal allografts in cynomolgus monkeys



14:15 - 16:20 PM   Plenary Session 8: Regulatory T Cells in Transplantation Tolerance (Ballroom, Friendship Palace)


                                   Chairs: Herman Waldmann (UK), Li Zhang (Canada)


14:15 - 14:40 PM       Herman Waldmann, University of Oxford, UK

                                    Explaining infectious tolerance


14:40 - 15:05 PM       Bruce Hall, University of New South Wales, Australia

                                   Antigen specific Tregs in transplant tolerance are dependent upon late Th1 and Th2 cytokines, IFN-g and IL-5


15:05 - 15:30 PM      Joost van Meerwijk, INSERM, France

                                   Prevention of actute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T cells


15:30 - 15:55 PM       Hans-Dieter Volk, Charite, Humboldt University, Germany

                                    Regulatory T cell therapy based on biomarker analysis – from animal models to clinical application? 


15:55 – 16:10 PM      Short Talk: Petra Reinke, Charité University Medicine Berlin, Germany

                                    Regulatory T cells in chronic CMV infection – negative impact on adoptive CMV specific T cell therapy in transplant patients


16:10 – 16:25 PM      Short Talk: Julia Tsang/Shuiping Jiang, Chinese Academy of Medical Sciences, China

                                    Adoptive alloantigen-specific Treg therapy for clinical transplantation tolerance



16:25 - 16:40 PM   Coffee Break



16:40 - 17:55 PM   Plenary Session 9: Regulatory T Cells in Regional and Airway Inflammation (Ballroom, Friendship Palace)


                                   Chairs: Fiona Powrie (UK), Dale Umetsu (USA)


16:40 - 17:05 PM       Fiona Powrie, University of Oxford, UK

                                    Regulatory T cells in intestinal homeostasis


17:05 - 17:30 PM       Dale Umetsu, Harvard University, USA

                                   The regulatory role of natural killer T cells in the airways


17:30 - 17:55 PM      Catherine Hawrylowicz, King's College London, UK

                                   Regulatory T cells in allergy and asthma: the role of the vitamin D pathway



17:55 - 19:00 PM   Plenary Session 10: Clinical Trials of Regulatory T Cells in Human Diseases (Ballroom, Friendship Palace)


                                   Chairs: Bruce Blazar (USA) and Matthias Edinger (Germany)


17:55 - 18:20 PM       Bruce Blazar, University of Minnesota, USA

                                    Ex vivo expansion of regulatory T cells (Tregs) from mice, non-human primates and humans for use in allogeneic stem cell transplantation


18:20 - 18:45 PM       Mattias Edinger, University of Regensbury, Germany

                                    Regulatory T cells in allogeneic stem cell transplantation


18:45 – 19:00 PM      Short Talk: Arnaud Foussat, TxCell, SA, France

                                    Immunotherapy of autoimmune diseases using autologous IL-10 producing Tr1 regulatory cells - A first injection trial in humans.



19:30 PM -               Gala Dinner (Ballroom or Juheyuan Restaurant, Friendship Palace)



Tuesday, October 28, 2008


8:00 -18:00 PM


Tour of the Great Wall, the Forbidden City, the 2008 Beijing Olympic venues, etc

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