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Friday, October
24, 2008
9:00
- 18:00 PM Registration (Lobby, Friendship Palace)
Saturday, October
25, 2008
8:00
- 8:15 AM Opening Ceremony (Ballroom, Friendship Palace)
Chairs: Shuiping Jiang (UK), George F Gao (China)
8:15
- 9:15AM Keynote Lecture (Ballroom, Friendship Palace)
Chair: Ethan Shevach, National Institutes of Health, USA
Shimon Sakaguchi, Kyoto University, Japan
Regulatory T cells for immune tolerance and homeostasis
9:15
- 9:30 AM Coffee Break
9:30
- 12:35 AM Plenary Session 1: Development and Molecular Control of Regulatory T Cells (Ballroom,
Friendship Palace)
Chairs: Alexander Rudensky (USA), Yong-Jun Liu (USA)
9:30
- 9:55 AM Alexander Rudensky, University of Washington, USA
Determinants of regulatory T cell development and function
9:55
- 10:20 AM Ludger Klein, University of Munich, Germany
Intrathymic development of natural regulatory T cells
10:20
- 10:45 AM Yong-Jun Liu, Anderson Cancer Center, USA
Two functional subsets of Foxp3+ regulatory T cells in human thymus and periphery
10:45
- 11:10 AM Thomas Malek, University of Miami, USA
IL-2 receptor signaling in T regulatory cell development, homeostasis, and function
11:10
- 11:35 AM Xuetao Cao, Second Military Medical University, China
Induction of regulatory T cells by regulatory antigen-presenting cells
11:35 - 11:50 AM
Short Talk: Yun-Cai Liu, La Jolla Institute for Allergy and Immunology, USA
The E3 ubiquitin ligase Itch regulates Foxp3 expression and airway inflammation
11:50 –12:05
PM Short Talk: Mike Farrar, University of Minnesota, USA
Linked T cell receptor and cytokine signaling govern the development of regulatory T cell repertoire
12:05 – 12:20
PM Short Talk: Jean Pieters, University of Basel, Switzerland
Regulation of T cell subsets by coronin 1 mediated intracellular signaling.
12:20 – 12:35
PM Short Talk: Li Wu, The Walter and Eliza Hall Institute of Medical Research, Australia
The migratory CD8loSirpa+ dendritic cell subset in the thymus is specialized in T-regulatory cell induction
12:35
- 14:40 PM Buffet Lunch (Juheyuan Restaurant, Friendship Palace), Poster Setup and
Poster Viewing (Poster Room, Friendship Palace)
13:10
- 14:20 PM Lunch Oral Session I (Ballroom, Friendship Palace)
Chairs: Kingston Mills (Ireland), Xiaoming Gao (China)
13:10 – 13:20
PM Biao Zheng, Baylor College of Medicine, USA
Germinal center helper T-cells are dual functional regulatory cells with suppressive activity to conventional CD4+ T-cells
13:20 – 13:30
PM Wenwei Tu, University of Hong Kong, China
Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naïve precursors by CD40-activated B cells
(0046)
13:30 – 13:40
PM Bin Wang, China Agricultural University, China
Suppression of antigen specific allergic and autoimmune responses by in vivo induction of regulatory DC that converts naïve
T cells to adaptive Tr cells
13:40 – 13:50
PM Hong Zhang, Northwestern University, USA
Induced PLP peptide-specific regulatory T cells appear to suppress experimental autoimmune encephalomyelitis in an antigen-specific
manner.
13:50 – 14:00
PM Frank J. Ward, University of
Aberdeen, UK
Stimulation of CD4+ regulatory T cells to secrete the effector T cell inhibitor, soluble CTLA-4
14:00 - 14:10 PM
Jude E. Uzonna, University of Manitoba, Canada
The phosphoinsotide 3 kinase (PI3K) controls susceptibility to Leishmania major by regulating expansion and effector function
of regulatory T cells
14:10 - 14:20 PM Amy Putnam, University of California at San Francisco, USA
Moving Tregs to the clinic: expansion and characterization of human regulatory T cells
14:40
- 16:25 PM Plenary Session 2: Induction of Regulatory T Cells (Ballroom, Friendship Palace)
Chairs: Harald von Boehmer (USA), Jingwu Zang (China)
14:40
- 15:05 PM Harald von Boehmer, Harvard University, USA
Prospective Treg induction by a single epitope achieves multi-epitope transplantation tolerance
15:05
- 15:30 PM Jingwu Zang, GlaxoSmithKline R&D China, China
Impaired function of regulatory T cells and role of T cell vaccination in rheumatoid arthritis
15:30 – 15:45
PM Short Talk: Stefan Beissert, University of Muenster, Germany
UV-induced regulatory T cells: phenotype and function
15:45 – 16:00
PM Short Talk: Xin Xiao Zheng, University of Pittsburgh, USA
A new pathway of differentiating double-negative regulatory T cells: novel cell-based therapeutic approach.
16:00
- 16:15 PM Coffee Break
16:15
- 18:05PM Plenary Session 3: Dynamics and Stability of Regulatory T Cells in Regulation (Ballroom,
Friendship Palace)
Chairs: Xuetao Cao (China), Jeffrey Bluestone (USA)
16:15
-16:40 PM Jeffrey Bluestone, University of California
at San Francisco, USA
Stability of Tregs critical in control of autoimmunity
16:40
- 17:05PM Ciriaco Piccirillo, McGill University, Canada
Functional dynamics of CD4+Foxp3+ regulatory T cells in organ-specific autoimmunity: In vivo veritas
17:05
- 17:20 PM Short Talk: Alf Hamann, Charite Berlin, Germany
Epigenetic regulation of Foxp3 and Treg stability
17:20
- 17:35 PM Short Talk: Xian C Li, Harvard University, USA
OX40 reprograms Foxp3+ Tregs to Foxp3+ inflammatory cells that mediate transplant rejection and autoimmunity
17:35
- 17:50PM Short Talk: Xiao-Feng Qin, MD Anderson Cancer Center, USA
The origin and dynamic behavior of tumor-associated Foxp3+ regulatory
T cells
17:50 – 18:05 PM Short Talk:
Makoto Miyara, Kyoto University, Japan; and University of Paris 6, France
Functional delineation and differentiation dynamics of
FoxP3-expressing subpopulations of CD4+ T cells in humans
18:40
- 22:00 PM Welcome Reception and Buffet Diner (Ballroom and Juheyuan Restaurant, Friendship Palace)
Sunday, October
26, 2008
8:00
- 10:30 AM Plenary Session 4: Mechanism of Suppression and Molecular Signaling of Regulatory T Cells
(Ballroom, Friendship Palace)
Chairs: Ethan Shevach (USA), Wanjun Chen (USA)
8:00
- 8:25 AM Ethan Shevach, National Institutes of Health, USA
Control of immune responses
by natural and adaptive regulatory T cells
8:25
- 8:50 AM Wanjun Chen, National Institutes of Health, USA
TGF-b control of CD4+CD25+Foxp3+
regulatory T cells: regulating the regulator
8:50
- 9:15 AM Megan Levings, University of British Columbia, Canada
Molecular regulation of human regulatory T cells
9:15
- 9:40 AM Yang-Xin Fu, University of Chicago, USA
Treg tempers initial innate responses
9:40
- 9:55 AM Short Talk: Bin Li, University of Pennsylvannia, USA
Foxp3 biochemistry in regulatory T cells - how diverse signals regulate suppression
9:55
- 10:10 AM Short Talk: Yisong Wan, University of North Carolina, USA
A critic and specific role for Brg in regulating Treg function
10:10 – 10:25 AM
Short talk: Ye Zheng, University of Washington, USA
Regulatory T cell suppressor program co-opts transcription factor IRF4 to control Th2 responses
10:25 – 10: 40 AM
Short Talk: Qizhi Tang, University of California, San Francisco, USA
Regulatory T cells impede autoimmune diabetes by preventing dendritic cell maturation in inflamed islets
10: 40 – 10:55 AM
Short Talk: Kristin Tarbell, National Institutes of Health, USA
The role of IL-1 inhibitors for regulatory T cell induction and function
10:55
- 11:10 AM Coffee Break
11:10
- 13:10 AM Plenary Session 5: Diversity of Regulatory T Cells (Ballroom, Friendship Palace)
Chairs: Maria Grazia Roncarolo (Italy), Wei He (China)
11:10
-11:35 AM Maria Grazia Roncarolo, San Raffaele Telethon Institute for Gene Therapy,
Italy
Biology and clinical application of natural and inducible regulatory T cells in humans
11:35
- 12:00PM Terry Delovitch, Robarts Research Institute, Canada
Extent of Treg-iNKT cell cooperation for protection from type 1 diabetes varies between treatment with Th2-biased and -unbiased
glycolipid antigents
12:00
- 12:25 PM Vipin Kumar, Torrey Pines Institute for Molecular Studies, USA
CD8aa+TCRab+ regulatory/suppressor T cells
12:25-
12:50 PM Li Zhang, University of Toronto, Canada
Double negative regulatory T cells - non-conventional regulators
12:50
- 13:10 PM Wei He, Chinese Academy of Medical Sciences, China
gd T cells in immunoregulation
13:10
- 14:45 PM Buffet Lunch (Juheyuan Restaurant, Friendship Palace), and Poster Viewing
(Rooms 1-3, Friendship Palace)
13: 40 –
14: 30 PM Lunch Oral Session II (Ballroom, Friendship Palace)
Chairs: Terry Delovitch (Canada), Baoping Wang (China)
13:40 – 13: 50
PM Itay Shalev, University of Toronto, Canada
The immunoregulatory role of FGL2 as a novel effector cytokine of Treg cells
13:50 – 14:00
PM Qing-Sheng Mi, Henry Ford Health System, USA
The miRNAs regulate iNKT cell development and maturation
14:00 – 14:10
PM Yan Wu, Harvard Medical School, USA
CD39/ENTPD1 expression by CD4+/Foxp3+ regulatory T cells inhibits NK cell-mediated antitumor activity
14:10 – 14:20
PM Leigh Guerin, University of Adelaide, Australia
The influence of interleukin 10 on regulatory T cell abundance in pregnancy
14:20 - 14:30 PM Asha Pillai, Stanford University, USA
Host natural killer T cells induce an IL-4 dependent expansion of donor CD4+CD25+Foxp3+ Tregs that protects against graft-versus-host
disease
14:45
- 16:35 PM Plenary Oral Session 1: Tregs: Basic Sciences (Ballroom, Friendship Palace)
Chairs: Richard Flavell (USA), Ludger Klein (Germany)
14:45 - 14:55 PM Georgina
Kalodimos, Centenary Institute of Cancer Medicine and Cell Biology, Australia
The role of T cell receptor avidity in thymic regulatory T cell development
14:55 - 15:05 PM Bernd
Arnold, German Cancer Research Center, Germany
Dickkopf 3, a novel modulator of T cell responses
15:05 - 15:15 PM Colleen
Winstead, University of Minnesota, USA
CD4+CD25+Foxp3+ regulatory T cells maintain peripheral tolerance in the context of T cell LIP through preservation of TCR
diversity
15:15 - 15:25 PM Zhaocai
Zhou, University of Pennsylvania School of Medicine, USA
Structural insights into FOXP3 homo-oligomerization
15:25 - 15:35 PM Nina
Oberle, German Cancer Research Center, Germany
Suppression mechanisms in human CD4+CD25- T cells upon interaction with naturally occurring regulatory T cells
15:35 - 15:45 PM Erika
Cretney, The Walter and Eliza Hall Institute of Medical Research, Australia
A
crucial role for Blimp-1 in regulatory T cells
15:45 - 15:55 PM Kajsa Wing,
Kyoto University, Japan
CTLA-4 expression is critical for CD4+Foxp3+ regulatory T cell function
15:55 - 16:05 PM Zihai
Li, University of Connecticut School of Medicine
Heat shock protein gp96 (grp94, HSP90b1) potentiates regulatory T cell function via chaperoning Toll-like receptor 4
16:05 - 16:15 PM Qian
Chen, National Institutes of Health, USA
Engagement of TLR2 promotes mouse regulatory T cell survival
16:15 - 16:25 PM Yogesh
Singh, The Royal Veterinary College, UK
Antigen-specific
designer regulatory T cells: an immunotherapeutic approach to ameliorate autoimmune type 1 diabetes
16:25 - 16:35 PM Karin Loser,
University of Muenster, Germany
CD4+CD25+
regulatory T cells expanded in peripheral lymph nodes via RANKL-RANKL activated epidermal Langerhans cells suppress cutaneous
inflammation and colitis
16:35 - 16:50 PM Coffee Break
16:40 -18:30 PM Plenary
Short Talk Session 2: Tregs: Clinical Application (Ballroom, Friendship Palace)
Chairs: Fiona Powrie (UK), Thomas Malek (USA)
16:50 - 17:00 PM Giuseppina
Pennesi, Advanced Biotechnology Center, Italy
Generation of CD4+C25+ Treg mediated by mesenchymal stem cells in experimentally induced sarcomas
17:00 - 17:10 PM Todd Brusko,
University of California at San Francisco, USA
Development of engineered antigen-specific human regulatory T cells by viral TCR gene transfer
17:10 - 17:20 PM Abdelaziz
Amrani, University of Sherbrooke, Canada
TSLP induces Treg differentiation and protection from autoimmune diabetes in NOD mice.
17:20 - 17:30 PM Ana Claudia Zenclussen, Otto-von-Guericke University, Germany
Regulatory T cells: Key players in maternal tolerance towards the fetus
17:30 - 17:40 PM Laurence
Weiss, Université Paris Descartes, France
Regulatory T cells in chronically HIV-infected patients interrupting an effective antiretroviral therapy
17:40 - 17:50 PM Raewyn Broady,
University of British Columbia, Canada
Development of a modified skin explant assay to study interactions between T regulatory and Th17 cells in human skin.
17:50 - 18:00 PM Xunrong
Luo, Northwestern University, USA
ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via expansion
of CD4+CD25+Foxp3+ Treg cells
18:00 - 18:10 PM Luis
Graca, University of Lisbon, Portugal
Induction of antigen-specific tolerance to aeroallergens: regulation without regulatory T cells.
18:10 - 18:20 PM David
Game, Imperial College London, UK
Tregs
in human transplantation: FoxP3 is not enough
18:20 - 18:30 PM Yang Dai,
Torrey Pines Institute for Molecular Studies, USA
Clonal choice mediated by processing of flanking residues of a dominant GAD65 determinant is involved in T cell regulation
in type 1 diabetes
18:45 - 19:30 PM Special
Session: Journal Editorial
Policies and Process (Ballroom, Friendship Palace)
Chairs: Shuiping Jiang (UK), Xuetao Cao (China)
Dr John Foley, Associate Editor of Science (Science Signaling)
Dr Clare Thomas, Senior Editor of Nature Medicine
Dr Christine Borowski, Senior Editor of Nature Immunology
Dr Lucy Bird, Acting Chief Editor of Nature Review Immunology
Monday, October
27, 2008
8:00
- 10:25 AM Plenary Session 6: Tregs, Teff, and Autoimmune Disease (Ballroom, Friendship
Palace)
Chairs: C Garrison Fathman (USA), David Hafler (USA)
8:00
- 8:25 AM C Garrison Fathman, Stanford University, USA
Treg and CD4+ Teff interactions result in anergy in the regulated cells
8:25
- 8:50 AM David Hafler, Harvard University, USA
The Balance of Human
CD4+CD25high Regulatory T cells and Th17 Effector Cells
8:50
- 9:15 AM Richard Flavell, Yale University, USA
Tregs and Th17 cell dynamics
9:15
- 9:40 AM Stephen Miller, Northwestern University, USA
A role for Tregs in controlling susceptibility/resistance and tolerance in immune-mediated demyelinating diseases
9:40 - 9:55 AM
Short Talk: Eva Huter, National Institutes of Health, USA
Antigen-specific TGF-beta-induced Treg suppress Th17-mediated autoimmune disease
9:55 – 10:10 AM Short Talk: Jean M Fletcher, Trinity College Dublin,
Ireland
CD39+ FoxP3+ Treg cells suppress pathogenic Th17 cells
10:10
- 10:25 AM Coffee Break
10:25
- 12:30 AM Plenary Session 7: Regulatory T Cells in Infection and Cancer (Ballroom, Friendship Palace)
Chairs: Weiping Zou (USA), Tyler J Curiel (USA)
10:25
- 10:50 AM Kingston H. G. Mills, Trinity College, Ireland
Manupulating Treg cell induction by modulating dendritic cell activation in the development of therapies for cancer and autoimmunity
10:50
- 11:15 AM Weiping Zou, University of Michigan, USA
Regulatory
T cell compartmentalization and trafficking
11:15
- 11:40 PM Tyler J Curiel, University of Texas Health Sciences Center, USA
Managing regulatory T cells as a novel cancer treatment strategy
11:40
- 11:55 PM Short Talk: Fu-Sheng Wang, Beijing Insitute of Infectious Diseases, China
Increased regulatory T cells impair CD8+ T-cell function and correlate with poor survival of patients with HBV-associated
hepatocellular carcinoma
11:55 - 12:10 PM Short Talk, Lishan Su, Institute of Biophysics, CAS, China
Distinctive roles of FoxP3+ Treg cells during acute & chronic HIV-1 infection & immuno-pathogenesis
12:10 - 12:25 PM Short Talk:
Philipp Beckhove, German Cancer Research Center, Germany
Identification of a highly individual and polyvalent repertoire of tumour antigen specific regulatory T cells in colorectal
cancer patients
12:25
- 14:15 PM Buffet Lunch (Juheyuan Restaurant, Friendship Palace), and Poster Viewing
(Rooms 1-3, Friendship Palace)
13:00 –
14:00 PM Lunch Oral Session III (Ballroom, Friendship Palace)
Chairs: Hans-Dieter Volk (Germany), Bing-Yi Shi (China)
13:00 – 13:10 PM Yanmei Han, Second Military Medical University,
China
CD69+CD4+CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-β1
13:10 –13:20 PM Yu-Fang
Cui, Institute of Radiation Medicine, China
Regulatoy T cell is associated with pathogenesis of mouse colitis and therapeutic effect of CLYSTER No.1 on colitis
13:20 – 13:30
PM Chung-Hao Chao, Chang Gung University, Taiwan, China
The role of TNFRII-expressed regulatory T cells in patients with decompensated liver cirrhosis
13:30 – 13:40
PM Yun Ma, King’s College London, UK
Predominance of intrahepatic Th1 effectors and impairment of CD4+CD25+ T-regs may contribute to the perpetuation of liver
damage in autoimmune hepatitis
13:40 – 13:50
PM Hongjun Wang, Harvard Medical School, USA
Bilirubin and carbon monoxide induce tolerance towards islet allograft by modulating T regulatory T cells
13:50 – 14:00
PM Huifang Chen, Université de Montréal, Canada
Adoptive transfer of CD4+CD25+ regulatory cells combined with low-dose sirolimus preserves suppressive function of regulatory
T cells and delayed acute rejection of renal allografts in cynomolgus monkeys
14:15
- 16:20 PM Plenary Session 8: Regulatory T Cells in Transplantation Tolerance (Ballroom, Friendship Palace)
Chairs: Herman Waldmann (UK), Li Zhang (Canada)
14:15
- 14:40 PM Herman Waldmann, University of Oxford, UK
Explaining infectious tolerance
14:40
- 15:05 PM Bruce Hall, University of New South Wales, Australia
Antigen specific Tregs in transplant tolerance are dependent upon late Th1 and Th2 cytokines, IFN-g
and IL-5
15:05
- 15:30 PM Joost van Meerwijk, INSERM, France
Prevention of actute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T cells
15:30
- 15:55 PM Hans-Dieter Volk, Charite, Humboldt University, Germany
Regulatory T cell
therapy based on biomarker analysis – from animal models to clinical application?
15:55 – 16:10
PM Short Talk: Petra Reinke, Charité University Medicine Berlin, Germany
Regulatory T cells in chronic CMV infection – negative impact on adoptive CMV specific T cell therapy in transplant
patients
16:10 – 16:25
PM Short Talk: Julia Tsang/Shuiping Jiang, Chinese Academy of Medical Sciences, China
Adoptive alloantigen-specific Treg therapy for clinical transplantation tolerance
16:25
- 16:40 PM Coffee Break
16:40
- 17:55 PM Plenary Session 9: Regulatory T Cells in Regional and Airway Inflammation (Ballroom, Friendship
Palace)
Chairs: Fiona Powrie (UK), Dale Umetsu (USA)
16:40
- 17:05 PM Fiona Powrie, University of Oxford, UK
Regulatory T cells in intestinal homeostasis
17:05
- 17:30 PM Dale Umetsu, Harvard University, USA
The regulatory role of natural killer T cells in the airways
17:30
- 17:55 PM Catherine Hawrylowicz, King's College London, UK
Regulatory T cells in allergy and asthma: the role of the vitamin D pathway
17:55 - 19:00 PM Plenary Session 10: Clinical
Trials of Regulatory T Cells in Human Diseases (Ballroom, Friendship Palace)
Chairs: Bruce Blazar (USA) and Matthias Edinger (Germany)
17:55
- 18:20 PM Bruce Blazar, University of Minnesota, USA
Ex vivo expansion of regulatory T cells (Tregs) from mice, non-human primates and humans for use in allogeneic stem cell transplantation
18:20 -
18:45 PM Mattias Edinger, University of Regensbury, Germany
Regulatory T cells in allogeneic stem cell transplantation
18:45 – 19:00
PM Short Talk: Arnaud Foussat, TxCell, SA, France
Immunotherapy of autoimmune diseases using autologous IL-10 producing Tr1 regulatory cells - A first injection trial in humans.
19:30
PM - Gala Dinner (Ballroom or
Juheyuan Restaurant, Friendship Palace)
Tuesday, October
28, 2008
8:00 -18:00 PM
Tour
of the Great Wall, the Forbidden City, the 2008 Beijing Olympic venues, etc
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